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N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
- Development stage
- Preclinical
- Lead developer
- University of California, Irvine
- Modality
- Small Molecules
01
Overview
N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2‑yl)methyl]pyrrolidin‑3‑yl}‑N'‑(3‑chlorobenzyl)ethane‑1,2-diamine is an experimental small molecule inhibitor designed to selectively target neuronal nitric oxide synthase (nNOS). The compound features an aminopyridine ring that mimics the guanidinium group of L‑arginine and anchors the molecule in the NOS active site. Its pyrrolidine ring positions a nitrogen atom for key interactions with conserved residues in nNOS and eNOS. Structural studies confirm its binding mode and selectivity for nNOS over other isoforms. It has been studied primarily as a research tool for understanding nitric oxide synthase inhibition but is not approved or marketed as a pharmaceutical product[5].
- Other names
- 6-{[(3S,4R)-4-[(2-{[(3-chlorophenyl)methyl]amino}ethyl)amino]pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amineN-{(3R,4S)-4-[(6-Amino-4-methylpyridin-2-Yl)methyl]-3-pyrrolidinyl}-N′-(3-chlorobenzyl)-1,2-Ethanediamine
02
Targets
NOS1 (nNOS)
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